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Published on: 2010-01-23
Released on: 2010-01-23
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With the invitation to edit this volume, I wanted to take the opportunity to assemble reviews on different aspects of circadian clocks and rhythms. Although most c- tributions in this volume focus on mammalian circadian clocks, the historical int- duction and comparative clocks section illustrate the importance of various other organisms in deciphering the mechanisms and principles of circadian biology. Circadian rhythms have been studied for centuries, but only recently, a mole- lar understanding of this process has emerged. This has taken research on circadian clocks from mystic phenomenology to a mechanistic level; chains of molecular events can describe phenomena with remarkable accuracy. Nevertheless, current models of the functioning of circadian clocks are still rudimentary. This is not due to the faultiness of discovered mechanisms, but due to the lack of undiscovered processes involved in contributing to circadian rhythmicity. We know for example, that the general circadian mechanism is not regulated equally in all tissues of m- mals. Hence, a lot still needs to be discovered to get a full understanding of cir- dian rhythms at the systems level. In this respect, technology has advanced at high speed in the last years and provided us with data illustrating the sheer complexity of regulation of physiological processes in organisms. To handle this information, computer aided integration of the results is of utmost importance in order to d- cover novel concepts that ultimately need to be tested experimentally. How artificial light is wrecking your sleep and what to ... Is It the Terrible Twos? Or Is It a Disrupted Gut Microbiome? RHR: The Functional Medicine Approach to High Cholesterol Should You Really Be Taking Fish Oil ... Home The EMBO Journal Shen Wang 1 Ucheor B Choi 2 Jihong Gong 3 Xiaoyu Yang 1 Yun Li 1 Austin L Wang 2 Xiaofei Yang (sunlittleflyathotmail.com) * 3 Axel T Brunger ... AMPK: a nutrient and energy sensor that maintains energy ... AMP-activated protein kinase (AMPK) is a crucial cellular energy sensor. Once activated by falling energy status it promotes ATP production by increasing the ... Circadian Homeostasis of Liver Metabolism Suppresses ... Figure 2. Chronic Jet Lag Induces Metabolic Syndrome and the Progression from NAFLD to NASH and Fibrosis (A) The levels of serum and hepatic biomarkers in control and ... Cell Metabolism - ScienceDirect.com In a recent issue of Cancer Cell Kettner and colleagues (2016) link disruption of normal circadian rhythms to NASH and associated liver cancer suggesting that ... MELATONIN: Uses Side Effects Interactions and Warnings ... Melatonin is a hormone found naturally in the body. Melatonin used as medicine is usually made synthetically in a laboratory. It is most commonly available in pill ... Neuroscience - Latest research and news Nature Find the latest research reviews and news about Neuroscience from across all of the Nature journals. CREB - Wikipedia CREB (cAMP response element-binding protein) is a cellular transcription factor. It binds to certain DNA sequences called cAMP response elements (CRE) thereby ... Circadian rhythm - Wikipedia The primary circadian clock in mammals is located in the suprachiasmatic nucleus (or nuclei) (SCN) a pair of distinct groups of cells located in the hypothalamus. Issue: Neuron - Cell x Two papers in this issue of Neuron by Saleem et al. (2017) and Storchi et al. (2017) show that increases in background light intensity trigger proportional ...
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